Training?on?a?Chip: A Multi?Organ Device to Study the Effect of Muscle Exercise on Insulin Secretion in Vitro

Organ-on-a-chip (OOC) devices bring innovative disease modeling and drug discovery approaches by providing biomimetic models of tissues organs in vitro combined with biosensors. Miniaturized biosensor systems tissue biofabrication techniques allow to create multiple on a chip highly controlling the experimental variables for high-content screening applications. In this work, multi-OOC integrated platform composed skeletal muscle pancreatic cells is fabricated study impact exercise insulin secretion. Both engineered are optical biosensing technology monitor real-time contraction-induced myokine secretion their effect beta-cells production. Using device, it demonstrated that induced directly myotubes contractions. The cross-talk would improve assays provide new model loss pancreas functionality associated diabetes mellitus.